Project Description

Citrus Bioflavonoid, Hesperidin is a Natural product for cancer-targeted therapy: The citrus flavonoids are potent chemopreventive agents. Except from the Cancer Chemoprevention Research Center, Faculty of Pharmacy.
This is why it makes a very potent ingredient in dissolving the ganglion cyst.

Citrus Bioflavonoid, Hesperidin may have beneficial effects on capillary permeability and blood flow and intern help to unblock the nucleus of the ganglionic cyst. Citrus Bioflavonoid, Hesperidin is a flavanone a glycoside found abundantly in citrus fruits. The antioxidant abilities may be stronger than those of vitamin C and E, depending on concentrations tested. Several examples of citrus flavonoids that are potential as chemotherapeutic agents are tangeretin, nobiletin, hesperetin, hesperidin, naringenin, and naringin.

Wikipedia: Flavonoids were found to be strong topoisomerase inhibitors (inhibits the negative cancer enzymes), which are common findings in neonatal acute leukemia. The DNA changes were increased by treatment with flavonoids in cultured blood stem cells when the data on all types of leukiama in the study were taken together, a beneficial effect of the high-flavonoid diet was seen. This property may be responsible for both an anticarcinogenic-proapoptotic effect and a carcinogenic, DNA damaging potential of the substances.

How Flavonoids might inhibit the negative cancer enzymes, is that in recent years, topoisomerases have become popular targets for cancer chemotherapy treatments. It is thought that topoisomerase inhibitors block the ligation step of the cell cycle, generating single and double stranded breaks that harm the integrity of the genome. Introduction of these breaks subsequently lead to apoptosis and cell death. The citrus bioflavonoids include hesperidin (a glycoside of the flavanone hesperetin),quercitrin, rutin (two glycosides of the flavonol quercetin), and the flavone tangeritin. In addition to possessing in vitro antioxidant activity and an ability to increase intracellular levels of vitamin C, rutin and hesperidin may have beneficial effects on capillary permeability and blood flow. They also exhibit anti-allergy and anti-inflammatory benefits of quercetin from in vitro studies.

Consumers and food manufacturers have become interested in flavonoids for their possible medicinal properties, especially their putative role in inhibiting cancer or cardiovascular disease

Its aglycone form is called hesperetin. It acts as an antioxidant according to in vitro studies. Various preliminary studies reveal novel pharmaceutical propertiesn vitro and in laboratory research, hesperidin has anti-inflammatory effects. Hesperidin is also a potential sedative, possibly acting through opioid or adenosine receptors. Hesperidin exhibited pronounced anticancer activity against some selected human carcinoma cell lines. Hesperidin also showed potential to penetrate the blood–brain barrier in an in vitro model

Natural products being rich of flavonoids are those fruits belong to the genus citrus. Ethanolic extract of Citrus reticulata and Citrus aurantiifolia peels showed anticarcinogenic, antiproliferative, co-chemotherapeutic and estrogenic effects.

Targeted therapy has been a very promising strategy of drug development research. Pre-clinical and clinical studies in chemoprevention field yielded many valuable data in preventing the onset of disease and suppressing the progress of their growth, making chemoprevention a challenging and a very rational strategy in future research.

Those flavonoids have been shown to possess inhibition activity on certain cancer cells growth through various mechanisms. Moreover, citrus flavonoids also perform promising effect in combination with several chemotherapeutic agents against the growth of cancer cells. Previous studies showed that tangeretin suppressed the growth of T47D breast cancer cells by inhibiting ERK phosphorylation.  Besides, citrus flavonoids also performed estrogenic effect in vivo. (For further information)

Department of Pharmacology and Toxicology, University of Western Ontario, London, Canada

Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.

Flavonoids, hesperetin and naringenin, were tested singly and in one-to-one combinations for their effects on proliferation and growth of a human breast carcinoma cell line, These experiments provide evidence of anticancer properties of orange juice and indicate that citrus flavonoids are effective inhibitors of human breast cancer cell proliferation in vitro, (For further information)

Multidrug Resistance Reversal and Apoptosis Induction in Human Colon Cancer Cells by Some FlavonoidsPresent in Citrus Plants.

Department of Biophysics, Wrocław Medical University 

Multidrug resistance (MDR) of cancer cells constitutes one of the main reasons for chemotherapy failure. The search for nontoxic modulators that reduce MDR is a task of great importance.It was concluded that the activity of Flavonoids Present in Citrus Plants against multidrug-resistant cancer cells may be enhanced by its apoptosis-inducing activity. (For further information)

Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.

Translational Sciences, Novartis Institute for Biomedical Research

PURPOSE: To conduct a mechanistic investigation of the interaction between aliskiren  (renin inhibitors used primarily in treatment of hypertension high blood pressure.) And hesperetin derived from grapefruit juice  in healthy subjects.

CONCLUSIONS: Grapefruit juice decreases exposure of aliskiren partially via inhibition of intestinal OATP1A2. (For further information)